Growing evidence suggests that accumulation of multiple alterations such as activation of proto-oncogenes and inactivation of tumor suppressor genes is responsible for the development and progression of digestive system cancer. Genetic instability of oncogenes such as microsatellite instability (MSI) and loss of heterozygosity (LOH) is probably linked to mutations in genes responsible for tumor-genesis, and they play vital roles in tumor clinical pathology. The studies of MSI and LOH of digestive system cancer have been focused on genetic instability of P53, P16 and FHIT, but few studies were seen in gene nm23H1……..

Original post by Heather Craven

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